In intramuscular ceftriaxone is well absorbed from the injection site and reach high concentrations in the serum. The bioavailability of the drug – 100%. The average plasma concentration is achieved 2-3 hours after injection. Repeated intramuscular or intravenous administration in doses of 500-2000 mg every 12 to 24 hours accumulation of ceftriaxone in a concentration that is 15% -36% higher what is nandrolone than the concentration obtainable by a single administration.
When administered in a dose of 1500 to 3000 mg of the period half-life is from 5.8 to 8.7 hours; volume of distribution – from 5.78 to 13.5 liters; plasma clearance – 0.58-1.45 l / h, renal clearance – 0.32-0.73 l / h. Ceftriaxone is reversibly bound to plasma proteins. From 33% to 67% of the drug is excreted unchanged by the kidneys, and the rest is excreted with the bile into the intestine, where biotransformed to the inactive metabolite. Penetration into the cerebrospinal fluid : in infants and in children with inflammation of the meninges ceftriaxone penetrates into the cerebrospinal fluid, while in the case bacterial meningitis in 17% of the average concentration of the drug in the plasma diffuses into the cerebrospinal fluid, which is about 4 times greater than in aseptic meningitis. 24 hours after intravenous administration of ceftriaxone 50-100 mg / kg body weight in the cerebrospinal fluid concentrations greater than 1.4 mg / l. In adult patients with meningitis over 2-24 hours after dosing of 50 mg / kg body weight, ceftriaxone concentration in what is nandrolone are much greater than the minimum inhibitory concentration for the most common causes of meningitis.
The infectious-inflammatory diseases caused by susceptible pathogens: sepsis; meningitis; disseminated Lyme borreliosis (early and late stages of the disease); infections of the abdominal cavity (peritonitis, biliary tract infections and gastrointestinal tract); infections of bones, joints, soft tissue, skin and wound infections; infections in patients with weakened immune systems; pelvic infection; kidney and urinary tract infections; respiratory tract infections, particularly pneumonia, and upper respiratory tract infection; genital infections, including gonorrhea.
to prevent infection in the postoperative period, phenylpropionate.
. Hypersensitivity to cephalosporins what is nandrolone.
Precautions : prescribe the drug for ulcerative colitis in the human liver and kidneys, enteritis and colitis associated with the use of antimicrobials; premature and newborn infants with hyperbilirubinemia; Pregnancy and lactation.
Pregnancy and lactation
Application Tsefsona during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus (ceftriaxone crosses the placental barrier).
If necessary, use Tsefsona during lactation should decide what is nandrolone the issue of termination of breastfeeding ( ceftriaxone is excreted in breast milk).